A l’initiative de Stéphane Hatem, directeur de l’UMRS 1166 et directeur général de l’IHU-Ican, le séminaire mensuel UMRS 1166 – ICAN a l’honneur d’accueillir
Patrick T. Ellinor, M.D. Ph.D.
Membre du Broad Institute, Harvard
Directeur de la Cardiovascular Disease Initiative et du Precision Cardiology Laboratory
Directeur du Cardiac Arrhythmia Service au Massachusetts General Hospital
Professeur de médecine à la Harvard Medical School
Membre du Consortium MAESTRIA (H2020)
jeudi 31 mars 2022 – Faculté de médecine Pierre et Marie Curie (105) – Amphi E à 14h
Genetics and single cell sequencing to identify new therapeutic targets for cardiovascular diseases
Cardiovascular diseases are the leading causes of death worldwide, yet there is an urgent need for new therapies. In the current talk, we will discuss three complimentary approaches for the discovery of new therapeutic targets – genetics, machine learning, and single cell sequencing. First, we will review the latest approaches to identify genes underlying cardiovascular diseases using genome wide association studies and large-scale sequencing. We will then discuss the application of machine learning to imaging data to define new cardiovascular traits. Finally, we will explore recent results from single cell sequencing in patients with dilated and hypertrophic cardiomyopathy that has identified a disease-specific upregulation of activated fibroblasts.