2-years postdoctoral research fellow position available in the “Molecular and Cellular Plasticity in
Cardiovascular Diseases” group at the UMRS 1166 – ICAN in Paris, France, under the direction of Dr
Sophie Nadaud. https://recherche-cardiovasculaire-metabolique.fr/
We seek to hire a highly motivated postdoctoral fellow to investigate the role of regulatory pathways
and of progenitor cells in vascular remodeling during hypertension in the team led by Dr Sophie
Nadaud at the UMRS 1166-ICAN. The UMRS 1166 – ICAN (Research unit on cardiovascular and
metabolic diseases) is a dynamic research center located in Paris center that comprises internationally
recognized groups focusing on cardiovascular and metabolic diseases. We offer a team oriented
environment in a multidisciplinary research lab with numerous up-to-date technical facilities on the
site (e.g. single cell RNAseq analysis…). Sorbonne University is ranked within the top 100 research
centers in the world (Times Higher Education ranking & QS World Ranking).
The post-doctorate will work with research assistants, students and scientists to study vascular
progenitors’ fate using various lineage tracing mouse models and various systemic hypertension
models. Vascular progenitor cells activity will also be studied in vitro. Experimental techniques will
include: animal models generation, echo-doppler analysis of vascular function, immunohistology and
immunofluorescence studies, progenitor cells FACS isolation and culture.
Highly motivated scientists with a strong interest in vascular pathophysiology are encouraged to apply.
The candidate should have a PhD in Life Sciences with a strong knowledge in vascular biology and
should be experienced in animal manipulation (formation in animal experimentation) and tissue
analysis (immunohistology, RT-PCR, Western-blots). Solid experience with fluorescence imaging
techniques (microscope and analysis software) is mandatory. Experience in hypertensive animal
models or FACS cell isolation and culture would also be appreciated but are not obligatory. Strong
writing and oral communication skills will be needed and good English language skills are necessary.
The candidate should have demonstrated innovation, initiative, problem-solving attitude, and ability
to work well both independently and as a member of a team. Applicants should have the willingness
to teach students and technicians. Working languages will be English and French.
The position, opened for two years (with a possibility of 6 months to one-year renewal), offers creative
and stimulating working conditions in dynamic and international research environment. Salary will be
in accordance with the University scale, depending on experience. The start date of the position is
approx. Dec 2021-January 2022. Application will be considered until the position is filled.
CV, list of publications, 1/2-page personal statement with short description of previous research
projects and experience, interests and contact information for (at least) two referees should be sent
by email to:
Publications related to the project
Dierick F, et al. Resident PW1+ Progenitor Cells Participate in Vascular Remodeling During Pulmonary Arterial
Hypertension. Circ Res. (2016) 118 (5):822-33. DOI: 10.1161/CIRCRESAHA.115.307035
Bordenave J, et al. Lineage Tracing Reveals the Dynamic Contribution of Pericytes to the Blood Vessel
Remodeling in Pulmonary Hypertension. Arterioscler Thromb Vasc Biol. 2020;40(3):766-782. DOI:
10.1161/ATVBAHA.119.313715
Guivarc’h E et al. Nuclear Activation Function 2 Estrogen Receptor α Attenuates Arterial and Renal Alterations
Due to Aging and Hypertension in Female Mice. J Am Heart Assoc. 2020 Mar 3;9(5):e013895. DOI:
10.1161/JAHA.119.013895