Events

Mathieu HAUTEFEUILLE – Progrès et limites de la conception de sinusoïde hépatique in-vitro sur puce : vers la construction de systèmes biomimétiques de culture multicellulaires – IBPS – May 30, 2023 – Bordeaux Room (105)

Date: 30 May 2023
Time: 12 h 30 min - 14 h 00 min
Location: Faculté de Médecine - 105 Bd de l'Hôpital - 75013 Paris - salle bordeaux
Monthly Lab Seminar

SEMINAIRE MENSUEL Umrs 1166 – ICAN

A l’invitation de Sophie Garnier, MCU SU (Eq. 1), le prochain séminaire mensuel Umrs 1166 – IHU-ICAN accueillera

Mathieu Hautefeuille

Professeur d’Université
Laboratoire de Biologie du Développement
Institut de Biologie Paris Seine
Sorbonne Université

Progrès et limites de la conception de sinusoïde hépatique in-vitro sur puce :vers la construction de systèmes biomimétiques de culture multicellulaires

Les systèmes de type organe sur puce (organ on chip) permettent d’imiter fidèlement in vitro la physiologie native du microenvironnement d’intérêt de tissus cibles. Pour cela, il est nécessaire de contrôler les propriétés mécaniques du tissu reconstitué (viscoelasticité, flux et cisaillement), son aspect multicellulaire et sa vascularisation, afin de pouvoir l’étudier dans des conditions proches du vivant. Nous montrerons l’exemple du foie sur puce, avec nos récents progrès permettant de construire un sinusoïde perfusé, suivant un processus de vasculogenesis fidèle au développement.

30 mai 2023 – 12h30
salle bordeaux
Faculté de médecine Pierre et Marie Curie
105 boulevard de l’Hôpital
75013 Paris

Présentiel et visioconférence
Inscription obligatoire à la visioconférence : https://us02web.zoom.us/meeting/register/tZIudeGtpjsiH9MFwq6wFFi8eLeyXoPTflLD

Professor Hossein ARDEHALI, MD, PhD – Northwestern University, Chicago – Role of Iron in Cardiovascular Diseases – April 28, 2023 – 2:00 pm – Room 329

Date: 28 April 2023
Time: 14 h 00 min - 17 h 00 min
Location: School of Medicine - 91 Bd de l'Hôpital - 75013 Paris - Room 514
Exceptional seminar
SEMINAIRE EXCEPTIONNEL Umrs 1166

A l’invitation de Stéphane Hatem, un séminaire exceptionnel accueillera

 

le Professeur Hossein Ardehali, MD, PhD
Directeur du Feinberg Cardiovascular and Renal Research Institute
Center for Molecular Cardiology
Northwestern University, Chicago, USA
 Role of Iron in Cardiovascular Diseases
28 avril 2023 – 14h
salle 329
Faculté de médecine Pierre et Marie Curie
91 boulevard de l’Hôpital
75013 Paris
Présentiel et visioconférence
Inscription obligatoire à la visioconférence

Franck BOCCARA – CHU Saint-Antoine – UMRS 938-Centre de recherche scientifique Saint-Antoine – Lp(a) and Aortic Valve Stenosis – April 20, 2023 – 12:45 pm – Room 514 (105)

Date: 20 April 2023
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Location: School of Medicine - 105 Bd de l'Hôpital - 75013 Paris - Room 514
Monthly Lab Seminar

Umrs 1166 – IHU-ICAN monthly seminar

At the invitation of Antonio Gallo (Team 5), the next Umrs 1166 – ICAN monthly seminar will host

Franck Boccara, MD, Ph.D., PU-PH
CHU Saint-Antoine
Umrs 938-Centre de recherche scientifique Saint-Antoine

Lp(a) and Aortic Valve Stenosis

April 20, 2023 – 12:45 pm
Room 514
School of Medicine
105 boulevard de l’Hôpital
75013 Paris

Face-to-face and videoconference
Mandatory registration for the videoconference:https://us02web.zoom.us/meeting/register/tZYuduihrDoqHNwN-CNVW3wVlYExk3BfdxBr

Isabelle DESCHENES-Professor and Chair-Dpt. Physiology and Cell Biology-Heart Failure and Arrhythmia-Ohio State Uni.-Regulation of the Cardiac Sodium Channel Nav1.5 by 14-3-3-March 21, 2023-12:30 pm to 2:00 pm-Room 514 (105)

Date: 21 March 2023
Time: 12 h 30 min - 14 h 00 min
Location: Room 514 - School of Medicine - 105 Bd de l'Hôpital - 75013 Paris
Monthly Lab Seminar

Invited by the Monthly Lab Seminar – Umrs1166-IHU ICAN, on behalf of Nathalie Neyroud, MD,, HDR

Isabelle Deschênes, PhD.- Professor and Chair Department of Physiology and Cell Biology – Bernie Frick Research Chair in Heart Failure and Arrhythmia – Ohio State University

Regulation of the cardiac sodium channel Nav1.5 by 14-3-3

The cardiac sodium channel Nav1.5 is responsible for the upstroke of the cardiac action potential. It is implicated in numerous cardiac diseases and it is regulated by several regulatory proteins. One of these interacting proteins is 14-3-3. In this seminar, we will cover the impact of 14-3-3 in regulating the cardiac sodium channel function.

Tuesday March 21, 2023

Room 514 – School of  Medicine – 105 boulevard de l’Hôpital – 75013 Paris

Marie GIZON – Nouvelle approche thérapeutique dans un modèle cellulaire humain du syndrome de Brugada – March 20, 2023 – 2:00 pm – School of Medicine-Room 505 (105)

Date: 20 March 2023
Time: 14 h 00 min
Location: Room 505 - School of Medicine - 105 Bd de l'Hôpital - 75013 Paris
PhD Defense

Marie GIZON defends her thesis (Nathalie Neyroud, PhD., HDR, superviser),

Nouvelle approche thérapeutique dans un modèle cellulaire humain du syndrome de Brugada

on Monday March 20, 2023 – 2:00 pm – Room 505 (105)

Lisa GOTTLIEB – MD, PhD – Univ. of Copenhagen – La fibrillation auriculaire et les veines pulmonaires – February 13, 2023 – 12:30 pm – School of Medicine (105) – Room 514

Date: 13 February 2023
Time: 12 h 30 min
Monthly Lab Seminar

Invited by the Monthly Lab Seminar – Umrs1166-ICAN, on behalf of Mikael Laredo, MD,

Lisa Gottlieb, MD, PhD

Department of Biomedical Sciences – University of Copenhagen

La fibrillation auriculaire et les veines pulmonaires

February 1, 2023 – 12:30 pm – School of Medicine (105) – Room 514

Abstract

Lorsque la pharmacothérapie échoue, l’ablation des veines pulmonaires reste une option pour traiter la fibrillation auriculaire symptomatique. Néanmoins, malgré cette intervention, 4 patients sur 10 ne seront pas guéris de leur arythmie. Une reconnexion électrique des veines pulmonaires est considérée comme étant la cause principale de cet échec. Cependant, il y a potentiellement d’autres facteurs impliqués. Ce séminaire sera une discussion autour de la physiopathologie de la veine pulmonaire et du rôle joué par l’étirement et les cicatrices rigides qui apparaissent à l’endroit des lésions d’ablation.

 

Santiago VERNIA – Imperial College London – Characterization of RNA Splicing Factors Involved in Metabolic Regulation in the Liver – January 31, 2023 – 12:30 pm – School of Medicine (105) – Bordeaux Room

Date: 31 January 2023
Time: 12 h 30 min
Location: School of Medicine - 105 Bd de l'Hôpital - 75013 Paris - salle bordeaux
Monthly Lab Seminar

Invited by Wilfried Le Goff, DR, Umrs 1166, Team 4 Head,

Santiago VERNIA

MRC Investigator
Metabolism and Gene Regulation Group
MRC London Institute of Medical Sciences
Hammersmith Hospital Campus

Characterization of RNA Splicing Factors Involved in Metabolic Regulation in the Liver

January 31, 2023 – 12:30 pm – School of Medicine (105) – Bordeaux room

Abstract
RNA splicing and alternative splicing expand the complexity and the regulatory potential of our genome. However, defects in these fundamental processes have been implicated in a growing number of human pathologies including liver disease. We will discuss recent advances and open questions about the contribution of RNA splicing and alternative splicing in metabolic homeostasis and inflammatory response in the liver.

Alexandre MOTTE – Amplitude de la réponse hypertriglycéridémique postprandiale: conséquences métaboliques et contribution des microARNs – December 14, 2022 – 2:00 pm – Room 510 – School of Medicine (105)

Date: 14 December 2022
Time: 14 h 00 min - 17 h 00 min
PhD Defense

Congratulations for such a beautiful defense!

Under the supervision of Dr. Maryse Guerin

PhD defense – Alexandre MOTTE

Amplitude de la réponse hypertriglycéridémique postprandiale: Conséquences métaboliques et contribution des microARNs

Wednesday December 14, 2022 – from 2:00 pm
Room 510 School of Medicine (105)

Chiara MACCHI – Pharm. and Mol. Biology Depart. – Univ. of Milano – Exploring the Role of Classical and Non-Classical Biomarkers in the Context of Atherosclerotic Burden – Nov. 24, 2022 – 12:30 – room 514 – School of Medicine (105)

Date: 24 November 2022
Time: 12 h 30 min - 14 h 00 min
Location: Room 514 - School of Medicine - 105 Bd de l'Hôpital - 75013 Paris
Monthly Lab Seminar

At the invitation of Antonio Gallo (Team 5), the Umrs1166-Ican monthly seminar has the honor and pleasure of wellcoming

Chiara MACCHI

Pharmacology and Molecular Biology Department – University of Milano

Exploring the role of classical and non-classical biomarkers in the context of atherosclerotic burden

November 24, 2022 – 12:30 pm to 2:00 pm

room 514 – School of Medicine – 105 boulevard de l’Hôpital 75013 Paris
Abstract: Cardiovascular risk stratification is a clinical challenge. Although lifestyle interventions and pharmacological strategies lowering low-density lipoprotein cholesterol (LDL-C) have led to a reduction in atherosclerotic cardiovascular disease (ASCVD), even among those with controlled LDL-C, ASCVD events continue to occur frequently. Thus, there is a need to identify new biomarkers improving the risk prediction for cardiovascular events. On this matter, emerging evidence emphasizes the importance of extracellular vesicles in intercellular communication processes with key effects on cell survival, endothelial homeostasis, inflammation, neoangiogenesis and thrombosis. Another aspect worth considering is related to mitochondria. They are responsible for the production of adenosine triphosphate (ATP) and the regulation of nutritional metabolism, calcium homeostasis and cellular viability in several organs. Pertaining cardiovascular burden, accumulation of mitochondrial DNA damage and progressive respiratory chain dysfunction are associated with atherosclerosis or cardiomyopathy in human investigations and animal models of oxidative stress. Mitochondrial dysfunction can also result in apoptosis, favoring plaque rupture. The characterization of extracellular vesicles and the study of mitochondrial functionality could thus pave the way for a better cardiovascular risk prediction as well as for promising therapeutic strategy in atherosclerosis.

Elise Balse and Camille Blandin – Application de l’analyse protéomique à l’étude du rôle d’une protéine d’échafaudage dans le cardiomyocyte – P3S Platform – Feedback Seminar – Thursday November 10, 2022 – 10:00 am to 12:00 pm – room 115 (91)

Date: 10 November 2022
Time: 10 h 00 min - 12 h 00 min

P3S Platform – Feedback Seminar

Thursday November 10, 2022 – 10 a.m. to 12 p.m. – Room 115 (91)

Program

10h00 : Présentation des applications proposées par P3S en génomique et protéomique

10:20 : Pierre-Yves Boëlle (Cinbios, UMS PASS)
Présentation du pôle bioinformatique de l’UMS

10:30 : Franck Bielle (U1127, ICM, Institut du cerveau et de la moëlle)
Application du méthylome à la classification des tumeurs cérébrales.

10:50 : Sylvie Briquet (U1135, CIMI, Centre d’Immunologie et des Maladies Infectieuses)
Genetic modifications in Plasmodium and genome analysis by long read sequencing.

11:10 : Elise Balse et Camille Blandin (UMRS 1166, Maladies cardiovasculaires et métaboliques)
Application de l’analyse protéomique à l’étude du rôle d’une protéine d’échafaudage dans le cardiomyocyte.

11:30 : Emmanuel Laplantine (U944, GenCellDis, Génomes, biologie cellulaire et thérapeutique, Hôpital Saint-Louis)
Des mutations de la déubiquitinase OTULINE prédisposent aux infections à staphylocoques chez l’homme: analyse protéomique de l’ubiquitination linéaire dans des fibroblastes issus de patients.

More details :

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