Events

Lisa GOTTLIEB – MD, PhD – Univ. of Copenhagen – La fibrillation auriculaire et les veines pulmonaires – February 13, 2023 – 12:30 pm – School of Medicine (105) – Room 514

Date: 13 February 2023
Time: 12 h 30 min
Monthly Lab Seminar

Invited by the Monthly Lab Seminar – Umrs1166-ICAN, on behalf of Mikael Laredo, MD,

Lisa Gottlieb, MD, PhD

Department of Biomedical Sciences – University of Copenhagen

La fibrillation auriculaire et les veines pulmonaires

February 1, 2023 – 12:30 pm – School of Medicine (105) – Room 514

Abstract

Lorsque la pharmacothérapie échoue, l’ablation des veines pulmonaires reste une option pour traiter la fibrillation auriculaire symptomatique. Néanmoins, malgré cette intervention, 4 patients sur 10 ne seront pas guéris de leur arythmie. Une reconnexion électrique des veines pulmonaires est considérée comme étant la cause principale de cet échec. Cependant, il y a potentiellement d’autres facteurs impliqués. Ce séminaire sera une discussion autour de la physiopathologie de la veine pulmonaire et du rôle joué par l’étirement et les cicatrices rigides qui apparaissent à l’endroit des lésions d’ablation.

 

Santiago VERNIA – Imperial College London – Characterization of RNA Splicing Factors Involved in Metabolic Regulation in the Liver – January 31, 2023 – 12:30 pm – School of Medicine (105) – Bordeaux Room

Date: 31 January 2023
Time: 12 h 30 min
Location: School of Medicine - 105 Bd de l'Hôpital - 75013 Paris - salle bordeaux
Monthly Lab Seminar

Invited by Wilfried Le Goff, DR, Umrs 1166, Team 4 Head,

Santiago VERNIA

MRC Investigator
Metabolism and Gene Regulation Group
MRC London Institute of Medical Sciences
Hammersmith Hospital Campus

Characterization of RNA Splicing Factors Involved in Metabolic Regulation in the Liver

January 31, 2023 – 12:30 pm – School of Medicine (105) – Bordeaux room

Abstract
RNA splicing and alternative splicing expand the complexity and the regulatory potential of our genome. However, defects in these fundamental processes have been implicated in a growing number of human pathologies including liver disease. We will discuss recent advances and open questions about the contribution of RNA splicing and alternative splicing in metabolic homeostasis and inflammatory response in the liver.

Alexandre MOTTE – Amplitude de la réponse hypertriglycéridémique postprandiale: conséquences métaboliques et contribution des microARNs – December 14, 2022 – 2:00 pm – Room 510 – School of Medicine (105)

Date: 14 December 2022
Time: 14 h 00 min - 17 h 00 min
PhD Defense

Congratulations for such a beautiful defense!

Under the supervision of Dr. Maryse Guerin

PhD defense – Alexandre MOTTE

Amplitude de la réponse hypertriglycéridémique postprandiale: Conséquences métaboliques et contribution des microARNs

Wednesday December 14, 2022 – from 2:00 pm
Room 510 School of Medicine (105)

Chiara MACCHI – Pharm. and Mol. Biology Depart. – Univ. of Milano – Exploring the Role of Classical and Non-Classical Biomarkers in the Context of Atherosclerotic Burden – Nov. 24, 2022 – 12:30 – room 514 – School of Medicine (105)

Date: 24 November 2022
Time: 12 h 30 min - 14 h 00 min
Location: Room 514 - School of Medicine - 105 Bd de l'Hôpital - 75013 Paris
Monthly Lab Seminar

At the invitation of Antonio Gallo (Team 5), the Umrs1166-Ican monthly seminar has the honor and pleasure of wellcoming

Chiara MACCHI

Pharmacology and Molecular Biology Department – University of Milano

Exploring the role of classical and non-classical biomarkers in the context of atherosclerotic burden

November 24, 2022 – 12:30 pm to 2:00 pm

room 514 – School of Medicine – 105 boulevard de l’Hôpital 75013 Paris
Abstract: Cardiovascular risk stratification is a clinical challenge. Although lifestyle interventions and pharmacological strategies lowering low-density lipoprotein cholesterol (LDL-C) have led to a reduction in atherosclerotic cardiovascular disease (ASCVD), even among those with controlled LDL-C, ASCVD events continue to occur frequently. Thus, there is a need to identify new biomarkers improving the risk prediction for cardiovascular events. On this matter, emerging evidence emphasizes the importance of extracellular vesicles in intercellular communication processes with key effects on cell survival, endothelial homeostasis, inflammation, neoangiogenesis and thrombosis. Another aspect worth considering is related to mitochondria. They are responsible for the production of adenosine triphosphate (ATP) and the regulation of nutritional metabolism, calcium homeostasis and cellular viability in several organs. Pertaining cardiovascular burden, accumulation of mitochondrial DNA damage and progressive respiratory chain dysfunction are associated with atherosclerosis or cardiomyopathy in human investigations and animal models of oxidative stress. Mitochondrial dysfunction can also result in apoptosis, favoring plaque rupture. The characterization of extracellular vesicles and the study of mitochondrial functionality could thus pave the way for a better cardiovascular risk prediction as well as for promising therapeutic strategy in atherosclerosis.

Elise Balse and Camille Blandin – Application de l’analyse protéomique à l’étude du rôle d’une protéine d’échafaudage dans le cardiomyocyte – P3S Platform – Feedback Seminar – Thursday November 10, 2022 – 10:00 am to 12:00 pm – room 115 (91)

Date: 10 November 2022
Time: 10 h 00 min - 12 h 00 min

P3S Platform – Feedback Seminar

Thursday November 10, 2022 – 10 a.m. to 12 p.m. – Room 115 (91)

Program

10h00 : Présentation des applications proposées par P3S en génomique et protéomique

10:20 : Pierre-Yves Boëlle (Cinbios, UMS PASS)
Présentation du pôle bioinformatique de l’UMS

10:30 : Franck Bielle (U1127, ICM, Institut du cerveau et de la moëlle)
Application du méthylome à la classification des tumeurs cérébrales.

10:50 : Sylvie Briquet (U1135, CIMI, Centre d’Immunologie et des Maladies Infectieuses)
Genetic modifications in Plasmodium and genome analysis by long read sequencing.

11:10 : Elise Balse et Camille Blandin (UMRS 1166, Maladies cardiovasculaires et métaboliques)
Application de l’analyse protéomique à l’étude du rôle d’une protéine d’échafaudage dans le cardiomyocyte.

11:30 : Emmanuel Laplantine (U944, GenCellDis, Génomes, biologie cellulaire et thérapeutique, Hôpital Saint-Louis)
Des mutations de la déubiquitinase OTULINE prédisposent aux infections à staphylocoques chez l’homme: analyse protéomique de l’ubiquitination linéaire dans des fibroblastes issus de patients.

More details :

Jérôme MONTNACH – Arrhythmogenic Right Ventricular Cardiomyoptahies: from Animal Models to Innovative Approaches – Nantes University – October 21 2022 – 12:00 – Room 122 (91)

Date: 21 October 2022
Time: 12 h 00 min
Location: Room 122 - School of Medicine - 91 Bd de l'Hôpital - 75013 Paris
Monthly Lab Seminar

Jérôme MONTNACH – CNRS Researcher
Thorax Institute – Nantes University

Arrhythmogenic Right Ventricular Cardiomyoptahies: from Animal Models to Innovative Approaches

October 21 2022 – 12:00
Room 122 – School of Medicine – 91 Bd de l’Hôpital – 75013 Paris

 

Abstract : Arrhythmogenic cardiomyopathy is an inherited heart muscle disorder, predisposing to sudden cardiac death, particularly in young patients. Pathological features include loss of myocytes and fibrofatty replacement of right ventricular myocardium. Molecular landscape linking loss of cell-to-cell junctions and arrhythmias is complex and involve many substrates. Dysregulation of calcium homeostasis appears as a key player in the arrhythmogenesis. In addition, this calcium dysregulation is a known trigger to various arrhythmias and an important target to prevent or terminate arrhythmias. In order to target specifically molecular actors to prevent or terminate arrhythmias, pharmacological approaches are not completely satisfying. In contrast, photopharmacology, by modulating compounds activity by light, allows high spatio-temporal resolution in the control of ion channels activity and opens the way to targeted pharmacology for arrhythmogenic patients. My lecture will showcase novel mechanisms involved in arrhythmogenic right ventricular cardiomyopathy and innovative pharmacological approaches to target specifically arrhythmogenic regions.

Visioconference link – mandatory registration: https://us02web.zoom.us/meeting/register/tZ0qc-qspzouHNNXI7OLyJabpgdFEWduq5sm

 

Cédric LE MAY – Actions extra-hépatiques de PCSK9 & Identification d’un variant de gain de fonction de LIPC – Health Research Institute – Nantes University – Thorax Institute – Team 4 Cardiometabolic Diseases – September 28 2022 – 12:30

Date: 28 September 2022
Time: 12 h 30 min
Location: Room 501 (105)
Monthly Lab Seminar

U1166-ICAN Monthly Lab Seminar 2022-2023

A l’invitation de Philippe Lesnik, Cédric Le May, DR CNRS, membre de l’Eq. 4 Maladies Cardiométaboliques de l’Institut du Thorax (Institut de Recherche en Santé de l’Université de Nantes) nous propose une intervention sur les

Actions extra-hépatiques de PCSK9 & Identification d’un variant de gain de fonction de LIPC

Les maladies cardiovasculaires athérosclérotiques représentent la principale cause de décès dans le monde et sont fortement influencées par des concentrations plasmatiques élevées en LDL-C.

La pro-protéine convertase subtilisine kexine de type 9 (PCSK9) a été initialement identifiée comme le 3ème gène impliqué dans l’hypercholestérolémie familiale. Elle agit comme un inhibiteur naturel endogène de la voie du récepteur au LDL en favorisant sa dégradation lysosomale. Au-delà du foie, PCSK9 est également exprimée à des niveaux significatifs dans d’autres tissus, où sa fonction reste peu claire. Notre équipe a contribué aux efforts visant à mieux comprendre ses fonctions extra-hépatiques en testant son rôle au niveau du pancréas endocrine, au niveau du rein, au niveau intestinal et plus récemment au niveau de la réponse immunitaire allergique. Ces travaux nous ont également permis de nous intéresser à une voie métabolique prometteuse mais mal caractérisée, l’Excrétion TransIntestinale de Cholestérol ou TICE, voie complémentaire à la voie hépatobiliaire dans l’élimination du cholestérol plasmatique.

Plus récemment dans le cadre de projet RHU CHOPIN, nous avons identifié et caractérisé un nouveau variant rare dans le gène LIPC (lipase hépatique) dans une famille qui présente une hypocholestérolémie familiale combinée dominante. Nos données mécanistiques ont mis en évidence que le variant E97G accroît l’activité phospholipase de la lipase hépatique, qui, en contrepartie, affecte fortement la clairance plasmatique et l’homéostasie du LDL-C.

September 28 2022 – 12:30

Room 501 (School of Medicine – 105 bd de l’Hôpital – 75013 PARIS)

Mandatory registration: https://us02web.zoom.us/meeting/register/tZUlfu-trzwuG9Bit4Ygq5SBuliYudW2hfIh

Jean-Baptiste PENIGAULT – Resolving Spatial Heterogeneity Using Nanostring’s High Precision and Single-Cell Profiling Platforms – May 20 2022 – 12:30 – Amphi D (91)

Date: 20 May 2022
Time: 12 h 30 min
Location: Amphi D (91)
Monthly Lab Seminar

Hosted by Nadine Suffee, Postdoctoral fellow, Team 3 Molecular and Cellular Plasticity in Cardiovascular Diseases, the monthly U1166-IHU seminar welcomes:

Jean-Baptiste PENIGAULT, PhD

Resolving Spatial Heterogeneity Using Nanostring’s High Precision and Single-Cell Profiling Platforms

May 20 2022 – 12:30 – Amphi D

Abstract: nanoString now offers two technologies for spatial profiling of tissue slices (Formalin Fixed Paraffine Embedded and Fresh/Fixed Frozen).

– The GeoMx® Digital Spatial Profiler (DSP) allows you to profile the Whole Exome and up to 140+ protein level in highly interdigitated compartments from human and murine tissue slices.

The unmatched precision of the GeoMx for Whole Transcriptome Analysis and its high through-put make it the ideal companion for your discovery studies.

– The CosMx™ Spatial Molecular Imager (SMI) allows you to elevate your single cell research with high-plex in situ spatial analysis. CosMx™ SMI is the first spatial biology platform to provide multiomics with any sample type at cellular and subcellular resolution. CosMx SMI enables rapid quantification and visualization of up to 1,000 RNA and 100 validated protein analytes. It is the flexible spatial single-cell solution driving deeper insights into the cell atlas, cell-cell interaction, cellular processes, and biomarker discovery.

 

Etienne KLEIN – Science and Research: on the Good Use of Doubt – Wednesday May 11 2022 – 6:15 pm – Sorbonne University – Pierre and Marie Curie Campus – Amphi 43

Date: 11 May 2022
Time: 18 h 15 min
Location: Sorbonne University - Pierre and Marie Curie Campus - Amphi 43
Passion for Sciences

Passion for Sciences Talks

Organisation : Isabelle Dusart (UMR 8246), Martine Glorian (UMRS 1166), Ingrid Lafontaine (UMR 7180)
contact:

Etienne Klein

Science and Research : on the Good Use of Doubt

Wednesday May 11 2022 – 6:15 pm

Sorbonne University Pierre et Marie Curie Campus – Amphi 43

 

Etienne Klein-Passion des sciences mai 2022V3(7)

Xavier PRIEUR – Thorax Institute – Inserm-Nantes University – Seipin Deficiency as a Model of Adipocyte Dysfunction – April 21 2022 at noon – Bordeaux Room – School of Medicine (105)

Date: 21 April 2022
Time: 12 h 00 min
Location: Bordeaux Room - School of Medicine 105 Bd de l'Hôpital 75013 PARIS - 5th floor
Monthly Lab Seminar

Hosted by Wilfried le Goff, head of Team 4 Cellular and Systemic Lipid Metabolism in Cardiometabolic Diseases, the UMRS 1166 – ICAN monthly seminar welcomes

Xavier Prieur, MCU
Thorax Institute UMR-S 1087 – Team 4 Cardiometabolic Diseases
Head of Biology Health Department
Nantes University – Inserm

Thursday April 21 2022 at 12:00

Pierre and Marie Curie School of Medicine (105) – Bordeaux Room (5th floor)

Seipin Deficiency as a Model of Adipocyte Dysfunction

Obesity is a major risk factor for cardiometabolic complications. Many studies show that adipocyte dysfunction is central to the development of these complications. In order to propose new therapeutic approaches, it is necessary to identify the factors that determine adipocyte homeostasis.

Seipin is an endoplasmic reticulum (ER) protein highly expressed in adipose tissue, encoded by the BSCL2 gene. In humans, the BSCL2 mutation is the cause of generalized lipodystrophy, characterized by an almost total absence of adipose tissue and serious metabolic complications. In our group we are interested in the function of seipin in the mature adipocyte and the metabolic consequences of seipin deficiency as a model of primary and extreme adipocyte dysfunction.

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