Research Unit on Cardiovascular and Metabolic Diseases
Situated in downtown Paris, in Pitié-Salpêtrière University Hospital, the research unit UMRS 1166-ICAN is located in Pierre and Marie Curie School of Medicine. Established in 2014 our lab was renewed in 2019 for a 5 new year period, under Inserm and Sorbonne Université tutorships.
It brings together 5 internationally recognized research teams with complementary interests and approaches in genetics, genomics, bioinformatics, molecular and cellular biology, physiology and pharmacology to bear upon cardiovascular and metabolic diseases.
As the primary cause of death in developed countries, cardiovascular and metabolic diseases share pathophysiological characteristics as diet, lifestyle, environment, genetic and epigenetic factors that contribute to disease progression, and are also their initial cause. Therefore interactions between basic and clinical research are critical in understanding them.
ICAN unit research teams are members of the Institute of Cardiometabolism and Nutrition IHU ICAN.
C. PAVOINE – Early Activation of the Cardiac CX3CL1/CX3CR1 Axis Delays β-Adrenergic-Induced Heart Failure – Sci Rep.2021 Sep
Early activation of the cardiac CX3CL1/CX3CR1 axis delays β-adrenergic-induced heart failure M Flamant, N Mougenot, E Balse, L Le Fèvre, F Atassi, EL Gautier, W Le Goff, M Keck, S Nadaud, C Combadière, A Boissonnas, C Pavoine Sci Rep. 2021 Sep 9;11(1):17982 PMID:...
S. NADAUD – Progenitor/Stem Cells in Vascular Remodeling during Pulmonary Arterial Hypertension – Cells.2021 May
Progenitor/Stem Cells in Vascular Remodeling during Pulmonary Arterial Hypertension France Dierick, Julien Solinc, Juliette Bignard, Florent Soubrier, Sophie Nadaud PMID: 34071347 PMCID: PMC8226806 DOI: 10.3390/cells10061338 Free PMC article Abstract Pulmonary...
Ph. CHARRON – Genome-wide association analysis in dilated cardiomyopathy reveals two new players in systolic heart failure on chromosomes 3p25.1 and 22q11.23 – Eur Heart J. 2021 Mar 3
Genome-wide association analysis in dilated cardiomyopathy reveals two new players in systolic heart failure on chromosomes 3p25.1 and 22q11.23. Garnier S, Harakalova M, Weiss S, Mokry M, Regitz-Zagrosek V, Hengstenberg C, Cappola TP, Isnard R, Arbustini E, Cook SA,...
M. GUERIN – Interleukin-1β and Risk of Premature Death in Patients With Myocardial Infarction. J Am Coll Cardiol. 2020;76(15):1763-1773.
Interleukin-1β and Risk of Premature Death in Patients With Myocardial Infarction Silvain J, Kerneis M, Zeitouni M, Lattuca B, Galier S, Brugier D, Mertens E, Procopi N, Suc G, Salloum T, Frisdal E, Le Goff W, Collet JP, Vicaut E, Lesnik P, Montalescot G, Guerin M. J...
AUTOMATE – Autophagy-Mediated Control of Tissue-Resident Macrophage Maintenance and Function
ANR AAPG 2020 AUTOMATE - Autophagy-mediated control of tissue-resident macrophage maintenance and function Coordinator Vincent Flacher - CNRS - Institute for Molecular and Cellular Biology (IBMC) Partners Frédéric Gros - UNISTRA and Institute for Molecular and...
EL GAUTIER – Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid Overload during Non-alcoholic Steatohepatitis. Immunity. 2020.
Tran S, Baba I, Poupel L, Dussaud S, Moreau M, Gélineau A, Marcelin G, Magréau-Davy E, Ouhachi M, Lesnik P, Boissonnas A, Le Goff W, Clausen BE, Yvan-Charvet L, Sennlaub F, Huby T, Gautier EL. Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid...
A. KONTUSH – HDL and Reverse Remnant-Cholesterol Transport (RRT): Relevance to Cardiovascular Disease. Trends Mol Med.2020 Dec;26(12)
Anatol Kontush HDL and Reverse Remnant-Cholesterol Transport (RRT): Relevance to Cardiovascular Disease Trends Mol Med.2020 Dec;26(12):1086-1100. doi: 10.1016/j.molmed.2020.07.005. Epub 2020 Aug 26. PMID: 32861590 DOI: 10.1016/j.molmed.2020.07.005 Abstract...
SN HATEM – Reactivation of the Epicardium at the Origin of Myocardial Fibro-Fatty Infiltration During the Atrial Cardiomyopathy. Circ Res. 2020 Mar 16.
Suffee N, Moore-Morris T, Jagla B, Mougenot N, Dilanian G, Berthet M, Proukhnitzky J, Leprince P, Trégouët DA, Puceat M, Hatem SN. Reactivation of the Epicardium at the Origin of Myocardial Fibro-Fatty Infiltration During the Atrial Cardiomyopathy. Circ Res. 2020 Mar...
Events
Fête de la Science – A Coeur Battant – UMRS 1166 Stall – Pierre and Marie Curie Campus – Sorbonne University – October 8, 9, 10
ICanBeGREEN 2nd Plenary Meeting – Tuesday October 5 2021 – 12:00 to 1:00 pm – Room TBN
Journée Impact carbone de la recherche et du numérique : enjeux, estimation et scénarii de réduction – Friday September 24 – 8:50 am to 12:30 pm
M. PUCEAT – Physiopathology of Cardiac Development – MMG – OCT4-Mediated Inflammation Induces Cell Reprogramming at the Origin of Cardiac Valve Development and Aortic Valve Calcification
NSFA E-CONGRESS 2021 – June 23-24 2021
Monthly Lab Seminar – C. BEZZINA – Amsterdam U. – Inherited Cardiac Disorders Affecting the Young; Beyond Monogenic Inheritance – June 14 2021
Monthly Lab Seminar – S. TALEB – PARCC – Immuno-metabolic Mechanisms of Cardiovascular Diseases – May 18 2021
SU – Concours ITRF 2021 – 15.02.2021-29.04.2021
