Postdoctoral position in immunometabolism.
2-3 year contract – Position to be filled on April 1, 2023 – Application deadline : January 31, 2023
Postdoctoral research fellow position available in the “Phagocytes in metabolic diseases” group led by
Emmanuel Gautier (http://www.emmanuelgautierlab.com/) at the UMRS 1166 in Paris, France.
The UMRS 1166 (Research Unit on Cardiovascular and Metabolic Diseases) is a dynamic research center
located in Paris that comprises internationally recognized groups focusing on cardiovascular and metabolic
diseases (https://recherche-cardiovasculaire-metabolique.fr/).
We seek to hire a highly motivated candidate to investigate the role of macrophages in metabolic diseases.
The candidate will work with research assistants and scientists to study how macrophage homeostasis and
functions are altered in metabolic diseases and how this in turn impact metabolic diseases-associated
comorbidities. To this aim transgenic mice and pre-clinical mouse models of metabolic diseases will be used
as well as patient clinical samples.
Highly motivated scientists with a strong interest in immunometabolism are encouraged to apply. The
candidate should have a PhD in Life Sciences with a strong knowledge in immunology and/or metabolism as
well as in molecular and cellular biology. Solid experience with animal experimentation is mandatory.
Experience in flow cytometry, imaging and molecular biology would also be appreciated. Strong writing and
oral communication skills will be needed. The candidate should have demonstrated innovation, initiative,
problem-solving attitude, and ability to work well both independently and as a member of a team. Working
languages will be French and English.
The position offers creative and stimulating working conditions in a dynamic and international research
environment. Salary will be in accordance with the Sorbonne University scale, depending on experience.
CV, list of publications, short description of previous research projects and experience, and contact
information for (at least) two referees should be sent by email to:
Publications related to the project
• Tran S, Baba I, Poupel L, Dussaud S, Moreau M, Gélineau A, Marcelin G, Magréau-Davy E, Ouhachi M, Lesnik P,
Boissonnas A, Le Goff W, Clausen BE, Yvan-Charvet L, Sennlaub F, Huby T, Gautier EL. Impaired Kupffer cell selfrenewal alters the liver response to lipid overload during non-alcoholic steatohepatitis. Immunity. 2020 Sep
15;53(3):627-640.
• Huby T, Gautier EL. Immune cell-mediated features of non-alcoholic steatohepatitis. Nat Rev Immunol. 2022
Jul;22(7):429-443.
• Marcelin M, Ferreirra A, Liu Y, Atlan M, Aron-Wisnewsky J, Pelloux V, Botbol Y, Ambrosini M, Fradet M, Rouault C,
Hénégar C, Mutel S, Hulot JS, Poitou C, Torcivia A, Nail Barthelemy R, Bichet JC, Gautier EL, Clement K. PDGFRamediated switch to CD9high progenitors controls fibrotic adipose tissue alteration in obesity. Cell Metabolism. 2017
Mar 7;25(3):673-685.
• Calippe B, Augustin S, Beguier F, Messance HC, Poupel L, Conart JB, Hu S, Lavalette S, Fauvet A, Rayes J, Levy O,
Raoul W, Fitting C, Denèfle T, Pickering MC, Harris C, Jorieux S, Sullivan PM, Sahel JA, Karoyan P, Paques M, Sapieha
P, Guillonneau X, Gautier EL, Sennlaub F. Complement factor H inhibits CD47-mediated resolution of inflammation.
Immunity. 2017 Feb 21;46(2):261-272.