Progenitor/Stem Cells in Vascular Remodeling during Pulmonary Arterial Hypertension
France Dierick, Julien Solinc, Juliette Bignard, Florent Soubrier, Sophie Nadaud
PMID: 34071347 PMCID: PMC8226806 DOI: 10.3390/cells10061338
Free PMC article
Abstract
Pulmonary arterial hypertension (PAH) is characterized by an important occlusive vascular remodeling with the production of new endothelial cells, smooth muscle cells, myofibroblasts, and fibroblasts. Identifying the cellular processes leading to vascular proliferation and dysfunction is a major goal in order to decipher the mechanisms leading to PAH development. In addition to in situ proliferation of vascular cells, studies from the past 20 years have unveiled the role of circulating and resident vascular in pulmonary vascular remodeling. This review aims at summarizing the current knowledge on the different progenitor and stem cells that have been shown to participate in pulmonary vascular lesions and on the pathways regulating their recruitment during PAH. Finally, this review also addresses the therapeutic potential of circulating endothelial progenitor cells and mesenchymal stem cells.
Keywords: endothelial cells; pericytes; progenitor cells; pulmonary arterial hypertension; smooth muscle cells; stem cells; vascular remodeling.