Jérôme MONTNACH – CNRS Researcher
Thorax Institute – Nantes University
Arrhythmogenic Right Ventricular Cardiomyoptahies: from Animal Models to Innovative Approaches
October 21 2022 – 12:00
Room 122 – School of Medicine – 91 Bd de l’Hôpital – 75013 Paris
Abstract : Arrhythmogenic cardiomyopathy is an inherited heart muscle disorder, predisposing to sudden cardiac death, particularly in young patients. Pathological features include loss of myocytes and fibrofatty replacement of right ventricular myocardium. Molecular landscape linking loss of cell-to-cell junctions and arrhythmias is complex and involve many substrates. Dysregulation of calcium homeostasis appears as a key player in the arrhythmogenesis. In addition, this calcium dysregulation is a known trigger to various arrhythmias and an important target to prevent or terminate arrhythmias. In order to target specifically molecular actors to prevent or terminate arrhythmias, pharmacological approaches are not completely satisfying. In contrast, photopharmacology, by modulating compounds activity by light, allows high spatio-temporal resolution in the control of ion channels activity and opens the way to targeted pharmacology for arrhythmogenic patients. My lecture will showcase novel mechanisms involved in arrhythmogenic right ventricular cardiomyopathy and innovative pharmacological approaches to target specifically arrhythmogenic regions.
Visioconference link – mandatory registration: https://us02web.zoom.us/meeting/register/tZ0qc-qspzouHNNXI7OLyJabpgdFEWduq5sm