Events

SEMINAIRE MENSUEL Umrs 1166 – ICAN

A l’invitation de Stéphane Hatem (Eq. 3), le prochain séminaire mensuel Umrs 1166 – IHU-ICAN accueillera

Erminia Donnarumma

Institut Pasteur

Les mitochondries sont primordiales pour le métabolisme et la survie des cardiomyocytes. Le processus de fission mitochondriale 1 (MTFP1) est une protéine de membrane mitochondriale interne (IMM) qui est dispensable pour la division mitochondriale mais essentielle au maintien de l’intégrité des mitochondries et de la santé cardiaque. L’élimination constitutive de MTFP1 dans les cardiomyocytes de souris entraîne une cardiomyopathie dilatée mortelle à l’âge adulte accompagnée d’un remodelage mitochondrial et cardiaque important pendant la transition vers l’insuffisance cardiaque. Avant l’apparition de la maladie, les mitochondries cardiaques knockout présentent des défauts IMM spécifiques: fuite futile de protons dépendant de la translocase nucléotidique adénine et sensibilité accrue à l’ouverture du pore de transition de perméabilité mitochondriale, avec lequel MTFP1 interagit physiquement et génétiquement. Collectivement, ces données révèlent de nouvelles fonctions de MTFP1 dans le contrôle de l’efficacité bioénergétique et de la sensibilité à la mort cellulaire et définissent son importance dans la prévention de la perte d’intégrité IMM et du remodelage cardiaque pathogène.

Salle 514
Faculté de médecine Sorbonne Université
91, boulevard de l’Hôpital
75013 Paris

28 juin 2023 – 12h30

Présentiel et visioconférence

Umrs 1166 – IHU-ICAN monthly seminar

At the invitation of Antonio Gallo (Team 5), the next Umrs 1166 – ICAN monthly seminar will host

Franck Boccara, MD, Ph.D., PU-PH
CHU Saint-Antoine
Umrs 938-Centre de recherche scientifique Saint-Antoine

Lp(a) and Aortic Valve Stenosis

April 20, 2023 – 12:45 pm
Room 514
School of Medicine
105 boulevard de l’Hôpital
75013 Paris

Face-to-face and videoconference
Mandatory registration for the videoconference:https://us02web.zoom.us/meeting/register/tZYuduihrDoqHNwN-CNVW3wVlYExk3BfdxBr

Invited by the Monthly Lab Seminar – Umrs1166-IHU ICAN, on behalf of Nathalie Neyroud, MD,, HDR

Isabelle Deschênes, PhD.- Professor and Chair Department of Physiology and Cell Biology – Bernie Frick Research Chair in Heart Failure and Arrhythmia – Ohio State University

Regulation of the cardiac sodium channel Nav1.5 by 14-3-3

Invited by the Monthly Lab Seminar – Umrs1166-ICAN, on behalf of Mikael Laredo, MD,

Lisa Gottlieb, MD, PhD

Department of Biomedical Sciences – University of Copenhagen

La fibrillation auriculaire et les veines pulmonaires

February 1, 2023 – 12:30 pm – School of Medicine (105) – Room 514

Abstract

Lorsque la pharmacothérapie échoue, l’ablation des veines pulmonaires reste une option pour traiter la fibrillation auriculaire symptomatique. Néanmoins, malgré cette intervention, 4 patients sur 10 ne seront pas guéris de leur arythmie. Une reconnexion électrique des veines pulmonaires est considérée comme étant la cause principale de cet échec. Cependant, il y a potentiellement d’autres facteurs impliqués. Ce séminaire sera une discussion autour de la physiopathologie de la veine pulmonaire et du rôle joué par l’étirement et les cicatrices rigides qui apparaissent à l’endroit des lésions d’ablation.

Invited by Wilfried Le Goff, DR, Umrs 1166, Team 4 Head,

Santiago VERNIA

MRC Investigator
Metabolism and Gene Regulation Group
MRC London Institute of Medical Sciences
Hammersmith Hospital Campus

Characterization of RNA Splicing Factors Involved in Metabolic Regulation in the Liver

January 31, 2023 – 12:30 pm – School of Medicine (105) – Bordeaux room

Abstract
RNA splicing and alternative splicing expand the complexity and the regulatory potential of our genome. However, defects in these fundamental processes have been implicated in a growing number of human pathologies including liver disease. We will discuss recent advances and open questions about the contribution of RNA splicing and alternative splicing in metabolic homeostasis and inflammatory response in the liver.

At the invitation of Antonio Gallo (Team 5), the Umrs1166-Ican monthly seminar has the honor and pleasure of wellcoming

Chiara MACCHI

Pharmacology and Molecular Biology Department – University of Milano

Exploring the role of classical and non-classical biomarkers in the context of atherosclerotic burden

November 24, 2022 – 12:30 pm to 2:00 pm

room 514 – School of Medicine – 105 boulevard de l’Hôpital 75013 Paris

Abstract: Cardiovascular risk stratification is a clinical challenge. Although lifestyle interventions and pharmacological strategies lowering low-density lipoprotein cholesterol (LDL-C) have led to a reduction in atherosclerotic cardiovascular disease (ASCVD), even among those with controlled LDL-C, ASCVD events continue to occur frequently. Thus, there is a need to identify new biomarkers improving the risk prediction for cardiovascular events. On this matter, emerging evidence emphasizes the importance of extracellular vesicles in intercellular communication processes with key effects on cell survival, endothelial homeostasis, inflammation, neoangiogenesis and thrombosis. Another aspect worth considering is related to mitochondria. They are responsible for the production of adenosine triphosphate (ATP) and the regulation of nutritional metabolism, calcium homeostasis and cellular viability in several organs. Pertaining cardiovascular burden, accumulation of mitochondrial DNA damage and progressive respiratory chain dysfunction are associated with atherosclerosis or cardiomyopathy in human investigations and animal models of oxidative stress. Mitochondrial dysfunction can also result in apoptosis, favoring plaque rupture. The characterization of extracellular vesicles and the study of mitochondrial functionality could thus pave the way for a better cardiovascular risk prediction as well as for promising therapeutic strategy in atherosclerosis.