Research Unit on Cardiovascular and Metabolic Diseases
Situated in downtown Paris, in Pitié-Salpêtrière University Hospital, the research unit UMRS 1166-ICAN is located in Pierre and Marie Curie School of Medicine. Established in 2014 our lab was renewed in 2019 for a 5 new year period, under Inserm and Sorbonne Université tutorships.
It brings together 5 internationally recognized research teams with complementary interests and approaches in genetics, genomics, bioinformatics, molecular and cellular biology, physiology and pharmacology to bear upon cardiovascular and metabolic diseases.
As the primary cause of death in developed countries, cardiovascular and metabolic diseases share pathophysiological characteristics as diet, lifestyle, environment, genetic and epigenetic factors that contribute to disease progression, and are also their initial cause. Therefore interactions between basic and clinical research are critical in understanding them.
ICAN unit research teams are members of the Institute of Cardiometabolism and Nutrition IHU ICAN.
T. HUBY & E.L. GAUTIER – Immune Cell-Mediated Features of Non...
Immune cell-mediated features of non-alcoholic steatohepatitis. Huby T, Gautier EL. Nat Rev Immunol. 2021 Nov 5:1-15. doi:...
N. NEYROUD – In vivo dominant-negative effect of an SCN5A Brugada ...
In vivo dominant-negative effect of an SCN5A Brugada syndrome variant. Doisne N, Grauso M, Mougenot N, Clergue M, Souil C, Coulombe A, Guicheney P,...
W. LE GOFF – Profound systemic alteration of the immune phenotype ...
Profound systemic alteration of the immune phenotype and an immunoglobulin switch in Erdheim-Chester disease in a single-center of 78 patients....
C. PAVOINE – Early Activation of the Cardiac CX3CL1/CX3CR1 Axis De...
Early activation of the cardiac CX3CL1/CX3CR1 axis delays β-adrenergic-induced heart failure M Flamant, N Mougenot, E Balse, L Le Fèvre, F Atassi,...
S. NADAUD – Progenitor/Stem Cells in Vascular Remodeling during Pu...
Progenitor/Stem Cells in Vascular Remodeling during Pulmonary Arterial Hypertension France Dierick, Julien Solinc, Juliette Bignard, Florent...
Ph. CHARRON – Genome-wide association analysis in dilated cardiomy...
Genome-wide association analysis in dilated cardiomyopathy reveals two new players in systolic heart failure on chromosomes 3p25.1 and 22q11.23....
M. GUERIN – Interleukin-1β and Risk of Premature Death in Patients...
Interleukin-1β and Risk of Premature Death in Patients With Myocardial Infarction Silvain J, Kerneis M, Zeitouni M, Lattuca B, Galier S, Brugier D,...
AUTOMATE – Autophagy-Mediated Control of Tissue-Resident Macrophag...
ANR AAPG 2020 AUTOMATE - Autophagy-mediated control of tissue-resident macrophage maintenance and function Coordinator Vincent Flacher - CNRS -...
Events
M. PERNOT – Deputy Director of Physics for Medicine – L’Echographie ultrarapide et ses applications – ESPCI Paris – PSL University – February 17 2022 – 12:30 to 2:00 pm – Bordeaux Room (105)
Stéphane CHARPIER – Entre les ondes de la mort et de la réanimation : l’insaisissable instant zéro – January 27 2022 – Pierre and Marie Curie Campus – Amphi 15 – 6:15 pm
C. LEGALLAIS – Liver on Chip and 3D Models – Head of the Laboratory of Biomechanics and Bioengineering – CNRS 7338 – Compiègne University of Technology – January 21 2022 – 12:30 to 2:00 pm – Bordeaux Room (105)
G. FRANCHINEAU – Apport de la tomographie par impédance électrique pour personnaliser la ventilation mécanique du patient présentant un syndrome de détresse respiratoire… – December 17th 2021 – Room J (105) – 2:00 pm
J. SOLINC – Remodelage vasculaire pulmonaire et HTAP : caractérisation des progéniteurs vasculaires pulmonaires PW1+ et régulation par la voie PDGFRα – December 14 2021 – Bordeaux Room (105) – 2:00 pm
F. ADER – Identification de variants du gène FLNC dans les cardiomyopathies humaines et modélisations fonctionnelles chez la drosophile et dans des pseudo-tissus cardiaques – December 8th 2021 – Room 26 (105) – 1:45 pm
L. SOULAT-DUFOUR – Place des biomarqueurs et des nouvelles techniques échocardiographiques dans l’évaluation du patient en fibrillation atriale – December 8 2021 – 2:30 pm – Room 112 – School of Medicine Saint-Antoine
Coralie SENGENES – Mobilisation endogène des cellules stromales adipeuses : un autre moyen de communication pour le tissu adipeux ? – STROMAGICS Team Leader – RESTORE Institute – November 30 2021
