Research Unit on Cardiovascular and Metabolic Diseases
Situated in downtown Paris, in Pitié-Salpêtrière University Hospital, the research unit UMRS 1166-ICAN is located in Pierre and Marie Curie School of Medicine. Established in 2014 our lab was renewed in 2019 for a 5 new year period, under Inserm and Sorbonne Université tutorships.
It brings together 5 internationally recognized research teams with complementary interests and approaches in genetics, genomics, bioinformatics, molecular and cellular biology, physiology and pharmacology to bear upon cardiovascular and metabolic diseases.
As the primary cause of death in developed countries, cardiovascular and metabolic diseases share pathophysiological characteristics as diet, lifestyle, environment, genetic and epigenetic factors that contribute to disease progression, and are also their initial cause. Therefore interactions between basic and clinical research are critical in understanding them.
ICAN unit research teams are members of the Institute of Cardiometabolism and Nutrition IHU ICAN.
P. HAUSFATER – Cumulative incidence of SARS-CoV-2 infection and as...
Cumulative incidence of SARS-CoV-2 infection and associated risk factors among frontline health care workers in Paris: the SEROCOV cohort study,...
A. KONTUSH – Phosphatidylserine Enhances Anti-inflammatory Effects...
Phosphatidylserine Enhances Anti-inflammatory Effects of Reconstituted HDL in Macrophages via Distinct Intracellular Pathways. Maryam Darabi, Marie...
C. PAVOINE – Early Protective Role of Inflammation in Cardiac Remo...
Early Protective Role of Inflammation in Cardiac Remodeling and Heart Failure: Focus on TNFα and Resident Macrophages. Sophie Besse, Sophie Nadaud,...
C. PAVOINE – Transcriptomic and Lipidomic Mapping of Macrophages i...
Transcriptomic and Lipidomic Mapping of Macrophages in the Hub of Chronic Beta-Adrenergic-Stimulation Unravels Hypertrophy-, Proliferation-, and...
T. HUBY & E.L. GAUTIER – Immune Cell-Mediated Features of Non...
Immune cell-mediated features of non-alcoholic steatohepatitis. Huby T, Gautier EL. Nat Rev Immunol. 2021 Nov 5:1-15. doi:...
N. NEYROUD – In vivo dominant-negative effect of an SCN5A Brugada ...
In vivo dominant-negative effect of an SCN5A Brugada syndrome variant. Doisne N, Grauso M, Mougenot N, Clergue M, Souil C, Coulombe A, Guicheney P,...
W. LE GOFF – Profound systemic alteration of the immune phenotype ...
Profound systemic alteration of the immune phenotype and an immunoglobulin switch in Erdheim-Chester disease in a single-center of 78 patients....
C. PAVOINE – Early Activation of the Cardiac CX3CL1/CX3CR1 Axis De...
Early activation of the cardiac CX3CL1/CX3CR1 axis delays β-adrenergic-induced heart failure M Flamant, N Mougenot, E Balse, L Le Fèvre, F Atassi,...
Events
Jean-Baptiste PENIGAULT – Resolving Spatial Heterogeneity Using Nanostring’s High Precision and Single-Cell Profiling Platforms – May 20 2022 – 12:30 – Amphi D (91)
Etienne KLEIN – Science and Research: on the Good Use of Doubt – Wednesday May 11 2022 – 6:15 pm – Sorbonne University – Pierre and Marie Curie Campus – Amphi 43
Xavier PRIEUR – Thorax Institute – Inserm-Nantes University – Seipin Deficiency as a Model of Adipocyte Dysfunction – April 21 2022 at noon – Bordeaux Room – School of Medicine (105)
Patrick T. ELLINOR – Genetics and single cell sequencing to identify new therapeutic targets for cardiovascular diseases – Broad Institute – Harvard – March 31 2022 – Amphi E (105) – 2:00 pm
Gilles BOEUF – L’humain dans le vivant – Tuesday March 22 2022 – SU – Pierre and Marie Curie Campus – Amphi 24 – 6:15 pm
Evelyne HEYER – L’Odyssée des gènes – February 17 2022 – 6:15 pm – Sorbonne University – Pierre and Marie Curie Campus – Amphi 44
M. PERNOT – Deputy Director of Physics for Medicine – L’Echographie ultrarapide et ses applications – ESPCI Paris – PSL University – February 17 2022 – 12:30 to 2:00 pm – Bordeaux Room (105)
C. LEGALLAIS – Liver on Chip and 3D Models – Head of the Laboratory of Biomechanics and Bioengineering – CNRS 7338 – Compiègne University of Technology – January 21 2022 – 12:30 to 2:00 pm – Bordeaux Room (105)
