Research Unit on Cardiovascular and Metabolic Diseases
Situated in downtown Paris, in Pitié-Salpêtrière University Hospital, the research unit UMRS 1166-ICAN is located in Pierre and Marie Curie School of Medicine. Established in 2014 our lab was renewed in 2019 for a 5 new year period, under Inserm and Sorbonne Université tutorships.
It brings together 5 internationally recognized research teams with complementary interests and approaches in genetics, genomics, bioinformatics, molecular and cellular biology, physiology and pharmacology to bear upon cardiovascular and metabolic diseases.
As the primary cause of death in developed countries, cardiovascular and metabolic diseases share pathophysiological characteristics as diet, lifestyle, environment, genetic and epigenetic factors that contribute to disease progression, and are also their initial cause. Therefore interactions between basic and clinical research are critical in understanding them.
ICAN unit research teams are members of the Institute of Cardiometabolism and Nutrition IHU ICAN.
Fundings : Fonds AMGEN France and Société Francophone du Diabète
O. BLUTEAU - Laureate Fonds AMGEN France Pour La Science et l’Humain SH-MetDiagRisk W. LE GOFF – Société Francophone du Diabète (SFD)
I. GUILLAS / W. LEGOFF- Regulation of HDL dysfunctionality by phosphatidylethanolamine links poly-unsaturated fatty acids with atherosclerotic cardiovascular diseases
I. GUILLAS / W. LEGOFF- Regulation of HDL dysfunctionality by phosphatidylethanolamine links poly-unsaturated fatty acids with atherosclerotic cardiovascular diseases. Mol Metab. 2025 Nov 15:102281. doi: 10.1016/j.molmet.2025.102281. PMID: 41248752 Regulation of HDL...
M. KERNEIS / M. GUERIN – Defective biological activities of high-density lipoprotein identify patients at highest risk of recurrent cardiovascular event
M. KERNEIS / M. GUERIN - Defective biological activities of high-density lipoprotein identify patients at highest risk of recurrent cardiovascular event. Eur J Prev Cardiol. 2025 Sep 22;32(13):1273-1285. doi: 10.1093/eurjpc/zwae356. PMID: 39506545 Defective biological...
P. LESNIK – MAIT Cells Promote Cholesterol Excretion Pathways Mitigating Atherosclerosis
P. LESNIK - MAIT Cells Promote Cholesterol Excretion Pathways Mitigating Atherosclerosis. Circ Res. 2025 Apr 25;136(9):968-981. doi: 10.1161/CIRCRESAHA.124.325841. Epub 2025 Mar 26. PMID: 40135347 MAIT Cells Promote Cholesterol Excretion Pathways Mitigating...
E. HAJDUCH / M. GUERIN- Inverse relationship between circulating sphingosine-1-phosphate and precursor species and coronary artery calcification score in type 2 diabetes
E. HAJDUCH / M. GUERIN- Inverse relationship between circulating sphingosine-1-phosphate and precursor species and coronary artery calcification score in type 2 diabetes. Cardiovasc Diabetol. 2025 Feb 21;24(1):85. doi: 10.1186/s12933-025-02624-9. PMID: 39984928...
W. LE GOFF – ABCG1 orchestrates adipose tissue macrophage plasticity and insulin resistance in obesity by rewiring saturated fatty acid pools
W. LE GOFF - ABCG1 orchestrates adipose tissue macrophage plasticity and insulin resistance in obesity by rewiring saturated fatty acid pools. Sci Transl Med. 2024 Dec 11;16(777):eadi6682. doi: 10.1126/scitranslmed.adi6682. PMID: 39661702 ABCG1 orchestrates adipose...
AROME, ANR 2023 Research Project, lead by Elise Balse, Estelle Gandjbakhch and Eric Villard (Teams 1 and 3), selected for phase 2.
Selected for phase 2 AROME, ANR 2023 call for projects, A research project lead by Elise Balse, Estelle Gandjbakhch and Eric Villard (Teams 1 and 3) Abstract Cardiac arrhythmias are a major cause of sudden death, stroke, and heart failure. Recent developments in...
Elise Balse and Camille Blandin – Application de l’analyse protéomique à l’étude du rôle d’une protéine d’échafaudage dans le cardiomyocyte – P3S Platform – Feedback Seminar – Thursday November 10, 2022 – 10:00 am to 12:00 pm – room 115 (91)
P3S Platform - Feedback Seminar Thursday November 10, 2022 – 10 a.m. to 12 p.m. - Room 115 (91) Program 10h00 : Présentation des applications proposées par P3S en génomique et protéomique 10:20 : Pierre-Yves Boëlle (Cinbios, UMS PASS) Présentation du pôle...
Events
Veronica Dahik – Lipid rewiring by adipose tissue macrophages during diet-induced inflammation and insulin resistance – Juin 28, 2023 – 2:00 pm – School of Medicine-Room bordeaux (105)
Erminia Donnarumma – The importance of mitochondrial inner membrane integrity in cardiac homeostasis – Juin 28, 2023 – Salle 514
Professor Hossein ARDEHALI, MD, PhD – Northwestern University, Chicago – Role of Iron in Cardiovascular Diseases – April 28, 2023 – 2:00 pm – Room 329
Franck BOCCARA – CHU Saint-Antoine – UMRS 938-Centre de recherche scientifique Saint-Antoine – Lp(a) and Aortic Valve Stenosis – April 20, 2023 – 12:45 pm – Room 514 (105)
Isabelle DESCHENES-Professor and Chair-Dpt. Physiology and Cell Biology-Heart Failure and Arrhythmia-Ohio State Uni.-Regulation of the Cardiac Sodium Channel Nav1.5 by 14-3-3-March 21, 2023-12:30 pm to 2:00 pm-Room 514 (105)
Lisa GOTTLIEB – MD, PhD – Univ. of Copenhagen – La fibrillation auriculaire et les veines pulmonaires – February 13, 2023 – 12:30 pm – School of Medicine (105) – Room 514
Santiago VERNIA – Imperial College London – Characterization of RNA Splicing Factors Involved in Metabolic Regulation in the Liver – January 31, 2023 – 12:30 pm – School of Medicine (105) – Bordeaux Room
Alexandre MOTTE – Amplitude de la réponse hypertriglycéridémique postprandiale: conséquences métaboliques et contribution des microARNs – December 14, 2022 – 2:00 pm – Room 510 – School of Medicine (105)
