Hosted by Stéphane Hatem, UMRS 1166 director and IHU-ICAN general director, the UMRS 1166 – ICAN monthly seminar welcomes
Patrick T. Ellinor, M.D. Ph.D.
Member of the Broad Institute, Harvard
Director of the Cardiovascular Disease Initiative and the Precision Cardiology Laboratory
Director of the Cardiac Arrhythmia Service at Massachusetts General Hospital
Professor of medicine at Harvard Medical School
MAESTRIA Consortium member (H2020)
Thursday March 31 2022 – Pierre and Marie Curie School of Medicine (105) – Amphi E at 2:00 pm
Genetics and single cell sequencing to identify new therapeutic targets for cardiovascular diseases
Cardiovascular diseases are the leading causes of death worldwide, yet there is an urgent need for new therapies. In the current talk, we will discuss three complimentary approaches for the discovery of new therapeutic targets – genetics, machine learning, and single cell sequencing. First, we will review the latest approaches to identify genes underlying cardiovascular diseases using genome wide association studies and large-scale sequencing. We will then discuss the application of machine learning to imaging data to define new cardiovascular traits. Finally, we will explore recent results from single cell sequencing in patients with dilated and hypertrophic cardiomyopathy that has identified a disease-specific upregulation of activated fibroblasts.